THE SELFISH BRAIN THEORY
Selfish-Brain
The Selfish Brain Clinical Research Group
www.selfish-brain.net 
Recent Publications:
Achim Peters, Professor of Internal Medicine, Endocrinology
Medical Clinic I, University of Luebeck, Germany

  1. H. Paulsen, T. Peters, V. Sinnwell, R. Lebuhn & B. Meyer, Liebigs Ann. Chem. (1984) 951-976, Bestimmung der Konformationen von Tri- und Tetrasaccharid-Sequenzen der Core-Struktur von N-Glycoproteinen. Problem der (1→6) glycosidischen Bindung.

  2. H. Paulsen, T. Peters, V.Sinnwell, R. Lebuhn & B. Meyer, Liebigs Ann. Chem. (1985) 489-509, Konformationen von Octasaccharid- & Pentasaccharid-Sequenzen in N-Glycoproteinen des Lactosamin-Typs.

  3. H. Paulsen, T. Peters, V. Sinnwell, M. Heume & B. Meyer, Carbohydr. Res. 156 (1986) 87-106, Konformationsanalyse der verzweigten Pentasaccharid-Sequenz der "Bisected" Struktur von N-Glycoproteinen.

  4. H. Paulsen, P. Himpkamp & T. Peters, Liebigs Ann. Chem. (1986) 664-674, Synthese von 1,6-Anhydromuramylpeptiden.

  5. C. A. A. van Boeckel, S. F. van Aelst, G. N. Wagenaars, J.-R. Mellema, H. Paulsen, T. Peters, A. Pollex & V. Sinnwell, Recl. Trav. Chim. Pays-Bas 106 (1987) 19-29, Conformational analysis of synthetic heparin like oligosaccharides containing α-L-idopyranosyluronic acid.

  6. H. Paulsen & T. Peters, Carbohydr. Res. 165 (1987) 229-249, Synthese von modifizierten Tetrasaccharid-Sequenzen der N-Glycoproteine.

  7. H. Paulsen, T. Peters, V. Sinnwell & B. Meyer, Carbohydr. Res. 165 (1987) 251-266, Konformationsanalyse modifizierter Tetrasaccharid-Sequenzen vom Typ der N-Glycoproteine - Zum Problem der α-(1→6)-glycosidischen Bindung.

  8. T. Peters & D. R. Bundle, J. Chem. Soc., Chem. Comm. (1987) 1648-1650, Synthesis of 4,6-Dideoxy-4-formamido-α-D-mannose containing Tri-, Tetra-, and Penta-saccharides, Antigenic Determinants of the Brucella A and M Antigens

  9. D. R. Bundle, M. Gerken & T. Peters, Carbohydr. Res. 174 (1988) 239-251, Synthesis of antigenic determinants of the Brucella A antigen, utilizing methyl-4-azido-4,6-dideoxy-α-D-mannopyranoside efficiently derived from D-mannose.

  10. T. Peters & D. R. Bundle, Can. J. Chem. 67 (1989) 491-496, Synthetic antigenic determinants of the Brucella A polysaccharide; A disaccharide thioglycoside for block synthesis of pentasaccharide and lower homologues of a 1,2 linked 4,6-dideoxy-4-formamido-α-D-mannose.

  11. T. Peters & D. R. Bundle, Can. J. Chem. 67 (1989) 497-502, Block Synthesis of two Pentasaccharide Determinants of the Brucella M antigen using thioglycoside methodologies.

  12. D. R. Bundle, J. W. Cherwonogrodzky, M. A. J. Gidney, P. J. Meikle, M. B. Perry & T. Peters, Infection and Immunity 57 (1989) 2829-2836, Definition of Brucella A and M Epitopes by Monoclonal Typing Reagents and Synthetic Oligosaccharides.

  13. T. Peters, J.-R. Brisson & D. R. Bundle, Can. J. Chem. 68 (1990) 979-988, Conformational Analysis of Synthetic Disaccharides, Key Components of Brucella A and M Antigens.

  14. K. Bock, H. Lönn & T. Peters, Carbohydr. Res. 198 (1990) 375 - 380, Conformational Analysis of a Disaccharide Fragment of the Polysaccharide Antigen of Streptococcus pneumonia Type I using NMR Spectroscopy and HSEA Calculations.

  15. T. Peters, Liebigs Ann. Chem. (1991) 135-141, Synthesis and Conformational Analysis of Methyl 2-O-(α-D-mannopyranosyl)-α-D-mannopyranoside.

  16. T. Peters & T. Weimar, Liebigs Ann. Chem. (1991) 237-242, Improved Synthesis of α-L-Fuc(1→4)-β-D-GlcNAc and α-L-Fuc(1→6)-β-D-GlcNAc Building Blocks: A Convergent Strategy employing O4-O6 Acetyl Migration. NOE Data for the protected 1,4-linked Disaccharide.

  17. A. Helander, L. Kenne, S. Oscarson, T. Peters & J.-R. Brisson, Carbohydr. Res. 230 (1992) 299-318, Synthesis, conformational and n.m.r. studies of α-D-mannopyranosyl and α-D-mannopyranosyl(1→2)α-D-mannopyranosyl linked to L-serine and L-threonine.

  18. T. Peters, B. Meyer, R. Stuike-Prill, R. Somorjai & J.-R. Brisson, Carbohydr. Res. 238 (1993) 49-73, A Monte Carlo Method for Conformational Analysis of Saccharides.

  19. T. Weimar, B. Meyer & T. Peters, J. Biomol. NMR 3 (1993) 399-414, Conformational Analyis of α-D-Fuc(1,4)-β-D-GlcNAc-OMe. One Dimensional Transient NOE Experiments and Metropolis Monte Carlo Simulations.

  20. T. Peters & T. Weimar, J. Biomol. NMR 4 (1994) 97-116, Assessing Glycosidic Linkage Flexibility: Conformational Analysis of the Repeating Trisaccharide Unit of Aeromonas salmonicida.

  21. T. Weimar & T. Peters, Angew. Chemie Int. Ed., 33 (1994) 88-91, Angew. Chemie 106 (1994) 79-82, Aleuria aurantia Agglutinin Recognizes Multiple Conformations of α-L-Fuc(1→6)-β-D-GlcNAc-OMe.

  22. K. Scheffler, B. Ernst, A. Katopodis, J. L. Magnani, W. T. Wang, R. Weisemann & T. Peters, Angew. Chem. 107 (1995) 2034-2037, Angew. Chem. Int. Ed., 34 (1995) 1841-1844, Determination of the Bioactive Conformation of the Carbohydrate Ligand in the E-Selectin/Sialyl Lewisx Complex.

  23. F. Casset, T. Peters, M. Etzler, E. Korchagina, N. Nifant’ev, S. Pérez & Anne Imberty, Eur. J. Biochem., 239 (1996) 710-719, Conformational analysis of blood group A trisaccharide in solution and in the binding site of Dolichos biflorus lectin using transient and transferred nuclear Overhauser enhancement (NOE) and rotating-frame NOE experiments.

  24. T. Peters and B. M. Pinto, Curr. Opin. Struct. Biol., 6 (1996) 710-720, Structure and dynamics of oligosaccharides: NMR and modeling studies.

  25. T. Weimar, A. Imberty, S. Pérez & T. Peters, Theochem, 395/396 (1997) 297-311, Combined NMR, Grid Search/MM3 and Metropolis Monte Carlo/GEGOP Studies of two α-L-Fucose Containing Disaccharides: α-L-Fuc-(1,4)-β-D-GlcNAc-OMe and α-L-Fuc-(1,6)-β-D-GlcNAc-OMe.

  26. F. Casset, A. Imberty, S. Pérez, M. Etzler, H. Paulsen & T. Peters, Eur. J. Biochem., 244 (1997) 242-250, Transferred nuclear Overhauser enhancement (NOE) and rotating-frame NOE experiments reflect the Size of the bound segment of the Forssman pentasaccharide in the binding site of Dolichos biflorus lectin.

  27. B. Meyer, T. Weimar & T. Peters, Eur. J. Biochem., 246 (1997) 705-709, Screening mixtures for biological activity by NMR.

  28. T. Sokolowski, T. Peters, S. Pérez & A. Imberty, J. Mol. Graph., 15 (1997) 1-7, Conformational Analysis of Biantennary Glycans and Molecular Modeling of Their Complexes with Lentil Lectin.

  29. K. Scheffler, J.-R. Brisson, R. Weisemann, J. L. Magnani, W. T. Wang, B. Ernst & T. Peters, J. Biomol. NMR, 9 (1997) 423-436, Application of homonuclear 3D NMR experiments and 1D analogs to study the conformation of sialyl LewisX bound to E-selectin.

  30. M. Rinnbauer, E. Mikros & T. Peters, J. Carbohydr. Chem., 17 (1998) 217-230, Conformational analysis of a complex between Dolichos biflorus lectin and the Forssman pentasaccharide using transferred NOE build-up curves.

  31. T. Sokolowski, T. Haselhorst, K. Scheffler, R. Weisemann, P. Kosma, H. Brade, L. Brade & T. Peters, J. Biomol. NMR, 12 (1998) 123-133, Conformational analysis of a Chlamydia-specific disaccharide α-Kdo-(2→8)-α-Kdo-(2→O)-allyl in aqueous solution and bound to a monoclonal antibody - observation of intermolecular transfer NOEs.

  32. T. Haselhorst, J.-F. Espinosa, J. Jiménez-Barbero, T. Sokolowski, P. Kosma, H. Brade, L. Brade & T. Peters, Biochemistry, 38 (1999) 6449-6459, NMR Experiments Reveal Distinct Antibody-Bound Conformations of a Synthetic Disaccharide Representing a General Structural Element of Bacterial Lipopolysaccharide Epitopes.

  33. D. Henrichsen, B. Ernst, J. L. Magnani, W.-T. Wang, B. Meyer & T. Peters, Angew. Chem. Int. Ed., 38 (1999) 98-102; Angew. Chem., 111 (1999) 106-110, Bioaffinity NMR Spectroscopy - Identification of an E-Selectin Antagonist in a Substance Mixture by Transfer NOE.

  34. L. Herfurth, T. Weimar & T. Peters, Angew. Chem. Int. Ed., 39 (2000) 2097-2099, Angew. Chem., 112 (2000) 2192-2194, Application of 3D-TOCSY-trNOESY for the assignment of bioactive ligands from mixtures.

  35. M. Vogtherr & T. Peters, J. Am. Chem. Soc., 122 (2000) 6093-6099, Application of NMR based binding assays to identify key hydroxy groups for intermolecular recognition.

  36. H. Maaheimo, P. Kosma, L. Brade, H. Brade, & T. Peters, Biochemistry 39 (2000) 12778-12788, Mapping the Binding of Synthetic Disaccharides Representing Epitopes of Chlamydial Lipopolysaccharide to Antibodies with NMR.

  37. W. Hellebrandt, T. Köhli, T. Haselhorst, E. Bäuml & T. Peters, J. Carbohydr. Chem., 19 (2000) 769-782, Synthesis of Four Deuterated Disaccharides for the Investigation of Protein-Carbohydrate Interactions - Application of Bioaffinity NMR.

  38. B. Ernst, Z. Dragic, S. Marti, C. Müller, B. Wagner, W. Jahnke, J. L. Magnani, K. E. Norman, R. Oehrlein, T. Peters & H. Kolb, Chimia, 55 (2001) 268-274, Design and Snythesis of E-Selectin Antagonists.

  39. T. Haselhorst, T. Weimar & T. Peters, J. Am. Chem. Soc., 123 (2001) 10705-10714, Molecular Recognition of Sialyl Lewisx and Related Saccharides by Two Lectins.

  40. T. Biet & T. Peters, Angew. Chemie, Int. Ed., 40 (2001) 4189-4192, Molecular Recognition of UDP-Gal by β-1,4-Galactosyltransferase T1.

  41. O. Kooistra, L. Herfurth, E. Lüneberg, M. Frosch, T. Peters, U. Zähringer, Eur. J. Biochem., 269 (2002) 573-582 Epitope mapping of the O-chain polysaccharide of Legionella pneumophila serogroup 1 lipopolysaccharide by saturation-transfer-difference NMR spectroscopy.

  42. A. Benie, R. Moser, E. Bäuml, D. Blaas & T. Peters, J. Am. Chem. Soc., 125 (2003) 14-15, Virus-Ligand Interactions: Identification and Characterization of Ligand Binding by NMR Spectroscopy

  43. T. Peters & B. Meyer , Angew. Chemie Int. Ed., 42 (2003)864-890; Angew. Chemie, 115 (2003) 890-918, Review article: NMR techniques for screening and identifying ligand binding to receptor proteins.

  44. M. Rinnbauer, B. Ernst, B. Wagner, J. Magnani, A. Benie, T. Peters , Glycobiology, 13 (2003) 435-443, Epitope Mapping of sialyl LewisX bound to E-selectin using saturation transfer difference NMR experiments.

  45. A. Bhunia, V. Jayalakshmi, A. Benie, O. Schuster, S. Kelm, H. Gäthje, N. R. Krishna, T. Peters, Carbohydr. Res., 339 (2003) 259-267, Saturation transfer difference NMR and computational modeling of a sialoadhesin-sialyllactose complex.

  46. V. Jayalakshmi, T. Biet, T. Peters, N. R. Krishna, J. Am. Chem. Soc. 126 (2004) 8610-8611, Refinement of the Conformation of UDP-Galactose Bound to GalactosyltransferaseUsing the STD NMR Intensity-Restrained CORCEMA Optimization.

  47. A. Blume, A. J. Benie, F. Stolz, R. R. Schmidt, W. Reutter, S. Hinderlich, Thomas Peters, J. Biol. Chem. 279 (2004) 55715-21. Characterisation of ligand binding to the bifunctional key enzyme in the sialic acid biosynthesis by NMR - Part I, investigation of the UDP-GlcNAc 2-epimerase functionality.

  48. A. J. Benie, A. Blume, R. R. Schmidt, W. Reutter, S. Hinderlich, Thomas Peters, J. Biol. Chem. 279 (2004) 55722-7. Characterisation of ligand binding to the bifunctional key enzyme in the sialic acid biosynthesis by NMR - Part II, investigation of the ManNAc kinase functionality.

  49. H. Peters, Y. Y. Kusov, S. Meyer, A. J. Benie, E. Bäuml, M. Wolff, C. Rademacher, T. Peters, V. Gauss-Müller, Biochem. J. 385 (2005) 363 - 70. Hepatitis A virus Proteinase 3C Binding to Viral RNA - Correlation with Substrate Binding and Enzyme Dimerization.

  50. R. Moser, L. Snyers, J. Wruss, J. Angulo, H. Peters, T. Peters, D. Blaas, Virology 338 (2005) 259 - 269. Neutralization of a common cold virus by concatemers of the third ligand binding module of the VLDL-receptor strongly depends on the number of modules.

  51. L. Herfurth, B. Ernst, B. Wagner, D. Ricklin, D. Strasser, J. L. Magnani, A. J. Benie, T. Peters, J. Med. Chem. 48 (2005) 6879-86. Comparative Epitope Mapping with STD NMR of sialyl Lewisa and Derivatives Bound to a Monoclonal Antibody

  52. C. Plath, T. Weimar, H. Peters, T. Peters, ChemBioChem 7 (2006) 1226-30. Assaying sialyltransferase activity with surface plasmon resonance.

  53. J. Angulo, B. Langpap, A. Blume, T. Biet, B. Meyer, N.R. Krishna, H. Peters, M.M. Palcic, T. Peters, J. Am. Chem. Soc. 128 (2006) 13529-13538. Blood Group B Galactosyltransferase: Insights into Substrate Binding from NMR Experiments.

  54. A. Blume, J. Angulo, T. Biet, H. Peters, A.J. Benie, M.M. Palcic, T. Peters, J. Biol. Chem. (2006) J. Biol. Chem. 281 (2006) 32728-32740. Fragment based screening of the donor substrate specificity of human blood group B galactosyltransferase using STD NMR.

  55. J. Angulo, C. Rademacher, T. Biet, A.J. Benie, A. Blume, H. Peters, M.M. Palcic, F. Parra, T. Peters, Methods Enzymol., Ed. M. Fukuda 416 (2006) 12-30. NMR analysis of carbohydrate-protein interactions.

  56. Rademacher, C.; Shoemaker, G. K.; Kim, H. S.; Zheng, R. B.; Taha, H.; Liu, C.; Nacario, R. C.; Schriemer, D. C.; Klassen, J. S.; Peters, T.; Lowary, T. L., Ligand specificity of CS-35, a monoclonal antibody that recognizes mycobacterial lipoarabinomannan: a model system for oligofuranoside-protein recognition. J Am Chem Soc 2007, 129, (34), 10489-502.

  57. Munch, J.; Standker, L.; Adermann, K.; Schulz, A.; Schindler, M.; Chinnadurai, R.; Pohlmann, S.; Chaipan, C.; Biet, T.; Peters, T.; Meyer, B.; Wilhelm, D.; Lu, H.; Jing, W.; Jiang, S.; Forssmann, W.-G.; Kirchhoff, F., Discovery and Optimization of a Natural HIV-1 Entry Inhibitor Targeting the gp41 Fusion Peptide. Cell 2007, 129, (2), 263-275.

  58. C. Rademacher & T. Peters, Molecular Recognition of Ligands by Native Viruses and Virus Like Particles as Studied by NMR Experiments Top. Curr. Chem., Vol. 273, in press

  59. C. Rademacher, N.R. Krishna, M. Palcic, F. Parra, T. Peters NMR Experiments Reveal the Molecular Basis of Receptor Recognition by a Calicivirus J. Am. Chem. Soc. in press